Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn’s disease
✍ Scribed by Yasunori Ogura; Lisa Saab; Felicia F Chen; Adalberto Benito; Naohiro Inohara; Gabriel Nuñez
- Book ID
- 117592255
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 858 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0888-7543
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## Background: The autophagy pathway has been linked with Crohn's disease (CD) through association of the ATG16L1 and IRGM genes with susceptibility for CD, and also to the Nod2 pathway, involved in CD. Our aim was to investigate polymorphisms in selected autophagy genes for their association with
Background: A German genome-wide nonsynonymous single nucleotide polymorphism (nsSNP) association study identified ATG16L1 as a Crohn's disease (CD) susceptibility gene. The association appeared to be confined to the nsSNP rs2241880 and was confirmed in 2 German independent case-control collections