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Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children

✍ Scribed by He, J-Q; Chan-Yeung, M; Becker, A B; Dimich-Ward, H; Ferguson, A C; Manfreda, J; Watson, W T A; Sandford, A J


Book ID
110037506
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
96 KB
Volume
4
Category
Article
ISSN
1466-4879

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## Abstract IL‐4 plays a pivotal role in the development of the Th2 cell mediated humoral immune response and causes IgE‐dependent allergic inflammatory diseases. Expression of IL‐4 in differentiated Th2 cells is regulated by transcription factors such as NF‐AT, AP‐1 and NF‐IL6. Recently, increasin