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Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development

✍ Scribed by Lingmin Hu; Xiangjun Zhai; Jibin Liu; Minjie Chu; Shandong Pan; Jie Jiang; Yixin Zhang; Hua Wang; Jianguo Chen; Hongbing Shen; Zhibin Hu

Book ID: 112097803
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 754 KB
Volume: 55
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.24799

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Chronic hepatitis B virus (HBV) infection is a major health issue, especially in Asia. A recent genome-wide association study (GWAS) implicated genetic variants in the human leukocyte antigen (HLA)-DP locus associated with chronic hepatitis B in Japanese and Thai populations. To confirm whether the