Genetic variability of purine nucleoside phosphorylase activity in the mouse: Relationship to Np-1 and Np-2

✍ Scribed by Floyd F. Snyder; Fred G. Biddle; Trevor Lukey; Marcia J. Sparling

• Publisher: Springer
• Year: 1983
• Tongue: English
• Weight: 414 KB
• Volume: 21
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00499142

✦ Synopsis

A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activity trait corresponding to Np-2 was inherited in an autosomal codominant manner and minor differences were apparent in thermal and kinetic properties between low- and high-activity strains. This work provides further support for there being either two structural loci for purine nucleoside phosphorylase, Np-1 and Np-2, or a regulatory-modifier locus.