Genetic Variability of HIV-1 Protease from Nigeria and Correlation with Protease Inhibitors Drug Resistance
β Scribed by Ana Carolina P. Vicente; Simon M. Agwale; Koko Otsuki; O.M. Njouku; D. Jelpe; J.A. Idoko; Elena Caride; Rodrigo M. Brindeiro; Amilcar Tanuri
- Book ID
- 110258882
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 107 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0920-8569
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π SIMILAR VOLUMES
The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure.
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## Abstract Development of drug resistance is considered a major cause for failure of antiretroviral therapy in human immunodeficiency virus type 1 (HIVβ1)βinfected patients adherent to treatment. However, the rate of emergence and the significance of HIVβ1 drug resistance in clinical practice have