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Genetic variability in the cytochrome P450–paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds

✍ Scribed by Clement E. Furlong

Book ID
102297690
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
489 KB
Volume
21
Category
Article
ISSN
1095-6670

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✦ Synopsis

In Table 1, the heading "Isozyme" was inadvertently added to column 1 of Table 1. As is clear from the table caption, the designations listed in this column refer to the donors for the liver microsomes being tested and no heading was intended or necessary.

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Genetic variability in the cytochrome P4
Genetic variability in the cytochrome P450–paraoxonase 1 (PON1) pathway for detoxication of organophosphorus compounds
✍ Clement E. Furlong 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 333 KB

## Abstract Detoxication of organophosphorus (OP) compounds is affected by genetic and environmental modulation of a number of enzymes involved in the process. For organophosphorothioate insecticides, different P450 isozymes and variants carry out two reactions that have quite different consequence