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Genetic vaccination approaches against malaria based on the circumsporozoite protein

✍ Scribed by Sandra Scheiblhofer; Richard Weiss; Josef Thalhamer


Publisher
Springer Vienna
Year
2006
Tongue
English
Weight
130 KB
Volume
118
Category
Article
ISSN
0043-5325

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The C terminus of the circumsporozoite protein (CSP) is anchored to the parasite cell membrane by a glycosylphosphatidylinositol (GPI) glycolipid. This GPI signal sequence functions poorly in heterologous eukaryotic cells, causing CSP retention within internal cell organelles during genetic immuniza