Removal of the circumsporozoite protein
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Sandra Scheiblhofer; Defeng Chen; Richard Weiss; Farhat Khan; Sven MostbΓΆck; Kon
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Article
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2001
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John Wiley and Sons
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English
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The C terminus of the circumsporozoite protein (CSP) is anchored to the parasite cell membrane by a glycosylphosphatidylinositol (GPI) glycolipid. This GPI signal sequence functions poorly in heterologous eukaryotic cells, causing CSP retention within internal cell organelles during genetic immuniza