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Genetic susceptibility linked to DR4 haplotypes in type 1a or polyendocrinopathy-associated (type-1b) diabetes

✍ Scribed by Bignon, J.D.; Semana, G.; Bardet, S.; Cheneau, M.L.; Maugendre, D.; Fauchet, R.; Muller, J.Y.; Genetet, B.; Allannic, A.; Sai, P.

Book ID
123242803
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
93 KB
Volume
32
Category
Article
ISSN
0198-8859

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The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association
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HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong