## Abstract Type 1 insulinβdependent diabetes is due to destruction of the insulin secreting cells of the islets of Langerhans. The disease is caused by nonβgenetic, probably environmental, factors operating in a genetically susceptible host to initiate a destructive immune process. These unknown e
Genetic susceptibility factors of Type 1 diabetes in Asians
β Scribed by Yongsoo Park; George S. Eisenbarth
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 169 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1520-7552
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Various environmental triggers, e.g. certain viruses and dietary factors, are thought to initiate the autoimmune process, leading to the destruction of pancreatic beta-cells and consequent Type 1 diabetes. A genetic predisposition is another prerequisite allowing the autoimmune process to progress.
Although Type 2 (non-insulin-dependent) diabetes mellitus (Type 2 DM) is more common in South Asians than in Europeans in the UK, very little is known about complications and their risk factors in South Asians. We sought microalbuminuria in a cross-sectional study of 583 European and 889 South Asian