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Genetic selection alters thermoregulatory response to ethanol

โœ Scribed by C.S. O'Connor; L.I. Crawshaw; J.C. Crabbe

Book ID
113225417
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
861 KB
Volume
44
Category
Article
ISSN
0091-3057

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It is widely accepted that the GABAergic system plays an important role in the action of ethanol in vivo. GABA transporter subtype 1 (GAT1) constructs high affinity reuptake sites in the CNS and regulates GABAergic transmissions. In this study, mice lacking the GAT1 were developed by homologous reco