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Genetic Screening in Hereditary Multiple Endocrine Neoplasia Type 1: Absence of a Founder Effect among Japanese Families

✍ Scribed by Sakurai, Akihiro ;Katai, Miyuki ;Itakura, Yasunori ;Nakajima, Koji ;Baba, Kiyoshi ;Hashizume, Kiyoshi


Book ID
108581269
Publisher
Wiley (Blackwell Publishing)
Year
1996
Tongue
English
Weight
513 KB
Volume
87
Category
Article
ISSN
0910-5050

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## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ proto‐oncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRα