Molecular genetic evidence for a founder
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Christine BΓ©tard; A. M. Kessling; M. Roy; A. Chamberland; S. Lussier-Cacan; J. D
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Article
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1992
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Springer
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English
β 786 KB
Familial hypercholesterolemia (FH), at a prevalence of about 1 in 200 in the French-Canadian population, is caused by a 10-kb deletion in the low-density lipoprotein (LDL) receptor gene in 60% of French-Canadian FH heterozygotes. We genotyped 159 FH patients who carry this common mutation and 221 he