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Genetic screen for presenilin-interacting genes in drosophila

✍ Scribed by Izhar Livne-Bar; Gabrielle L. Boulianne


Book ID
117412085
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
378 KB
Volume
21
Category
Article
ISSN
0197-4580

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## Abstract The γ‐secretase complex is involved in cleaving transmembrane proteins such as Notch and one of the genes targeted in Alzheimer's disease known as amyloid precursor protein (APP). Presenilins function within the catalytic core of γ‐secretase, and mutated forms of presenilins were identi