Genetic regulation of the antibody response to H-2Dballoantigens in mice

✍ Scribed by Dorothee Wernet

• Publisher: Springer-Verlag
• Year: 1982
• Tongue: English
• Weight: 632 KB
• Volume: 16
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00364443

✦ Synopsis

The cytotoxic antibody response to the H-2D b alloantigen has been investigated in ten strains of the C57BL/10 background. Three types of responses could be distinguished: no detectable response, an IgM response, and an IgG response. The IgG response is influenced by the D and probably the 1-A region of the H-2 complex, whereas the IgM response is dependent on the allele for the E~ chain. The hypothesis is proposed that regulatory T cells, which recognize the antigen in context of self MHC molecules, determine the outcome of an anti-H-2D b immunization in which the I-E molecule restricts the IgM response and the I-A molecule restricts the IgG response; the D molecule is probably responsible for activation of suppressor T cells which suppress only the IgG response.