Genetic regulation of slowly progressing mild muscle atrophy in fast-twitch muscles of BUF/Mna rats
✍ Scribed by Hiroyuki Amo; Mitsuhiro Saito; Shizuko Nagao; Shigeru Yagiu; Hisahide Takahashi; Hiroyuki Morita; Takako Matsuyama Morita; Mutsushi Matsuyama
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 84 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0148-639X
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✦ Synopsis
BUF/Mna strain rats spontaneously develop slowly progressing mild-moderate muscle atrophy of extensor digitorum longus, tibialis, and extraocular muscles, which consist mainly of fast-twitch type fibers, at nearly 100% incidence. They have lighter extensor digitorum longus muscles than soleus muscles, when alive for more than 6 weeks. Genetic segregation of the development of the muscle atrophy was studied by crossing the BUF/ Mna strain with three other strains, ACI/NMs, WKY/NCrj, and BDIX, which were free of muscle atrophy. Two autosomal dominant susceptible genes, Mas-1 and Mas-2, determine the development of the muscle atrophy in these combinations of crosses.