Studies were undertaken to investigate two critical aspects of the glucose-6-phosphate dehydrogenase polymorphism in Drosophila melanogaster. The first investigation unequivocally maps the genetic site of the G6PD locus to the X chromosome. The second study subjects a set of isochromosomal lines to
Genetic regulation of glucose 6-phosphate dehydrogenase activity inDrosophila melanogaster
โ Scribed by Mark W. Steele; William J. Young; Barton Childs
- Publisher
- Springer
- Year
- 1969
- Tongue
- English
- Weight
- 643 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0006-2928
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Three alleles of the Zw locus of Drosophila melanogaster--ZwA, ZwB, and Zwlol--apparently code for dimeric, tetrameric, and monomeric forms of glucose-6-phosphate dehydrogenase (G6PD), respectively. The three forms of G6PD are characterized by different apparent Km values for glucose-6-phosphate but
Two X-linked mutations that give rise to overproduction of glucose-6-phosphate dehydrogenase (G6PD) were found among the progenies of isogenic strains which had been subjected to selection for high G6PD activity. Mapping of the high-activity factor in these mutants was carried out using car ZwB sw m
There are two structural forms of glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster. Whether one or the other or both show in vitro (and probably in vivo) activity depends on the genotype of a sex-linked locus (Zw). In this article, the relative fittnesses of heterozygotes (with