✦ LIBER ✦

Genetic regulation of androgen action

✍ Scribed by Kallio, Pekka J.; Palvimo, Jorma J.; Jänne, Olli A.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 663 KB
Volume: 29
Category: Article
ISSN: 0270-4137
DOI: 10.1002/(sici)1097-0045(1996)6+<45::aid-pros9>3.0.co;2-j

No coin nor oath required. For personal study only.

✦ Synopsis

The androgen receptor (AR) belongs to the superfamily of nuclear receptors that employ complex genetic mechanisms to guide the development and physiological functions of different target tissues. Upon interaction with its cognate hormone, AR activates or represses gene transcription through association with specific DNA elements andlor proteins. This review summarizes briefly our current view of androgen action, with a special emphasis on genetic factors that may modulate the response.

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