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Genetic rearrangements in relation to immunophenotype and outcome in T-cell acute lymphoblastic leukaemia

✍ Scribed by Jules P.P. Meijerink


Book ID
116305203
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
323 KB
Volume
23
Category
Article
ISSN
1521-6926

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ABL1 rearrangements in T-Cell acute lymp
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## Abstract T‐cell acute lymphoblastic leukemia (T‐ALL) is the result of multiple oncogenic insults of thymocytes. Recently, new __ABL1__ fusion genes have been identified that provide proliferation and survival advantage to lymphoblasts. These are the __NUP214‐ABL1__ fusion gene, on amplified epis