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Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk

✍ Scribed by Zhai, R.; Liu, G.; Asomaning, K.; Su, L.; Kulke, M. H.; Heist, R. S.; Nishioka, N. S.; Lynch, T. J.; Wain, J. C.; Lin, X.; Christiani, D. C.


Book ID
121724141
Publisher
Oxford University Press
Year
2008
Tongue
English
Weight
87 KB
Volume
29
Category
Article
ISSN
0143-3334

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## Abstract Abnormalities of the tumor suppressor TP53 pathway are critical in the development of many cancers since it regulates cell cycle components and apoptosis. Murine double minute‐2 (MDM2) protein is a central node in the p53 pathway and a direct negative regulator of p53. The __MDM2 SNP309