Genetic polymorphisms of TP53-binding protein 1 (TP53BP1) gene and association with breast cancer risk
β Scribed by RAKESH NAIDU; YIP CHENG HAR; NUR AISHAH MOHD TAIB
- Book ID
- 109344191
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 89 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0365-5555
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## Abstract Single nucleotide polymorphisms (SNPs) were searched for in 36 genes involved in diverse DNA repair pathways, and 50 nonsynonymous (associated with amino acid changes) SNPs identified were assessed for associations with lung cancer risk by a caseβcontrol study consisting of 752 adenocar
The tumor suppressor TP53 pathway plays a crucial role in preventing carcinogenesis through its ability to impose cell cycle arrest and apoptosis following DNA damage and oncogene activation. MDM2 is a key negative regulator of the TP53 pathway and is overexpressed in many cancers as oncoprotein. We