Genetic polymorphisms in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene and prostate cancer risk in Caucasian men
β Scribed by Anastasios Karatzas; Eirini Giannatou; Vassilios Tzortzis; Stavros Gravas; Evangellos Aravantinos; George Moutzouris; Michael Melekos; Aspasia Tsezou
- Book ID
- 108078814
- Publisher
- Elsevier
- Year
- 2010
- Tongue
- English
- Weight
- 166 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1877-7821
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## Abstract CYP1A1 is likely to play an important role in the etiology of CaP through its function in activating environmental procarcinogens and catalyzing the oxidative metabolites of estrogens. To test the hypothesis that genetic polymorphisms in the __CYP1A1__ gene may be associated with the ri
## Abstract UDPβglucuronosyltransferase 1A1 (UGT1A1) is an enzyme which catalyses not only the glucuronidation of tobacco smoke carcinogens like benzopyrene, but also of the endogenous substrate bilirubin. Bilirubin for a long time was considered to be only a toxic waste product of hemoglobin degra