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Genetic polymorphisms in CYP1B1, GSTA1, NQO1 and NAT2 and the risk of lung cancer

✍ Scribed by Mette Sørensen; Herman Autrup; Anne Tjønneland; Kim Overvad; Ole Raaschou-Nielsen

Book ID
116333462
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
99 KB
Volume
221
Category
Article
ISSN
0304-3835

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## Abstract Tobacco smoking and occupation are major risk factors of bladder cancer via exposure to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Glutathione S‐transferase (GST) M1, T1 and P1 are involved in the detoxification of PAH reactive metabolites. Two __N__‐acetyltransferase