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Genetic polymorphisms for the study of multifactorial stroke

✍ Scribed by A. Bersano; E. Ballabio; N. Bresolin; L. Candelise

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
292 KB
Volume
29
Category
Article
ISSN
1059-7794

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✦ Synopsis

Communicated by Richard G.H. Cotton

Single-gene disorders explain only a minority of stroke cases. Stroke represents a complex trait, which is usually assumed to be polygenic. On this topic, the role of a wide number of candidate genes has been investigated in stroke through association studies, with controversial results. Therefore, it is difficult for the clinician to establish the validity and the level of clinical applicability of the previously reported associations between genetic factors and stroke. This review is an update and an extensive analysis of the more recent association studies conducted in stroke. We evaluated a number of studies on several candidate genes (including F5,

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