Genetic polymorphism of the rat aldehyde dehydrogenase 2 and the severity of experimental alcohol-induced liver damage
โ Scribed by Masayoshi Yamauchi; Yoshihiko Maezawa; Shyunya Satoh; Yuji Mizuhara; Gotaro Toda
- Book ID
- 113402438
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 596 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0928-4346
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๐ SIMILAR VOLUMES
Liver aldehyde dehydrogenase (ALDH), the enzyme involved in the oxidation of aldehydes such as acetaldehyde derived from ethanol, exists in multiple forms in most mammals. Up to five separable forms have been identified from the cytosolic fraction of Wistar rat liver. We investigated the genetic bas
Little is known about factors determining individual susceptibility to the physical complications of alcohol abuse but genetically determined differences in ethanol metabolism may be important. The oxidative metabolism of alcohol is catalyzed by alcohol and aldehyde dehydrogenase. Polymorphisms have