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Genetic polymorphism of mephenytoin p(4′)-hydroxylation: difference between Orientals and Caucasians.

✍ Scribed by M Jurima; T Inaba; D Kadar; W Kalow


Book ID
117943752
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
589 KB
Volume
19
Category
Article
ISSN
0306-5251

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The Far Eastern and Caucasian populations are strikingly different with respect to the debrisoquine/sparteine hydroxylation polymorphism. The number of poor metabolizers, as defined for Caucasians, is very low among Chinese and Japanese. We investigated the molecular basis for this difference by ana