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Genetic polymorphism in the manganese superoxide dismutase gene is associated with an increased risk for hepatocellular carcinoma in HCV-infected Moroccan patients

✍ Scribed by Sayeh Ezzikouri; Abdellah Essaid El feydi; Abdelaziz Chafik; Rajae Afifi; Latifa El kihal; Mustapha Benazzouz; Mohammed Hassar; Pascal Pineau; Soumaya Benjelloun


Book ID
116759322
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
119 KB
Volume
649
Category
Article
ISSN
1383-5718

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## Abstract The miR‐34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR‐34 function can impair p53‐mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of __pri‐miR‐34b/c__ (423 bp from th