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Genetic organization of the unc-22IV gene and the adjacent region in Caenorhabditis elegans

✍ Scribed by Rogalski, Teresa M. ;Baillie, David L.

Publisher: Springer
Year: 1985
Tongue: English
Weight: 685 KB
Volume: 201
Category: Article
ISSN: 0026-8925
DOI: 10.1007/bf00331331

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✦ Synopsis

The genetic organization of the region immediately adjacent to the unc-22 IV gene in Caenorhabditis elegans has been studied. We have identified twenty essential genes in this interval of approximately 1.5-map units on Linkage Group IV. The mutations that define these genes were positioned by recombination mapping and complementation with several deficiencies. With few exceptions, the positions obtained by these two methods agreed. Eight of the twenty essential genes identified are represented by more than one allele. Three possible internal deletions of the unc-22 gene have been located by intra-genic mapping. In addition, the right end point of a deficiency or an inversion affecting the adjacent genes let-56 and unc-22 has been positioned inside the unc-22 gene.

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