Genetic Mutations Involved in Melanoma: A Summary of Our Current Understanding
β Scribed by High, Whitney A.; Robinson, William A.
- Book ID
- 123472388
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 274 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0882-0880
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Germline mutations of the CDKN2A gene are found in melanoma-prone families and individuals with multiple sporadic melanomas. The encoded protein, p16(INK4A), comprises four ankyrin-type repeats, and the mutations, most of which are missense and occur throughout the entire coding region, can disrupt