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Genetic mosaicism in normal tissues of Wilms' tumour patients

✍ Scribed by Chao, Lian-Yu; Huff, Vicki; Tomlinson, Gail; Riccardi, Vincent M.; Strong, Louise C.; Saunders, Grady F.


Book ID
109915124
Publisher
Nature Publishing Group
Year
1993
Tongue
English
Weight
565 KB
Volume
3
Category
Article
ISSN
1061-4036

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W T l , the Wilms' tumour suppressor gene located at chromosome llp13, plays an important role in the development of the kidney. It is mutated in 10 per cent of Wilms' tumours (WTs) and their putative precursors called nephrogenic rests (NRs). A sensitive immunohistochemical technique was establishe