๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Genetic mosaicism at the insulin locus in liver associated with childhood hepatoblastoma

โœ Scribed by Dr. Lisa A. Simms; Anthony E. Reeve; Peter J. Smith

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
153 KB
Volume
13
Category
Article
ISSN
1045-2257

No coin nor oath required. For personal study only.

โœฆ Synopsis

Hepatoblastoma is commonly associated with loss of heterozygosity (LOH) involving chromosome region I I p 15.5. This region may contain an as yet unidentified tumor suppressor gene relevant to this and other tumors associated with the Beckwith-Wiedemann syndrome. Using the insulin (INS) locus as a marker for this region we have identified two of three patients with hepatoblastoma whose livers demonstrated genetic mosaicism. One tumor arose from the clone demonstrating LOH in the liver while the other arose from the clone without LOH. Genes Chromosom Cancer 13:72-73 (1995).

๐Ÿ“œ SIMILAR VOLUMES

Association of a Pvull RFLP at the lipop
Association of a Pvull RFLP at the lipoprotein lipase locus with fasting insulin levels in Hispanic men
โœ S. A. Cole; C. E. Aston; R. F. Hamman; R. E. Ferrell ๐Ÿ“‚ Article ๐Ÿ“… 1993 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 765 KB

## Abstract We present results from an association study between RFLPs in the lipoprotein lipase (LPL) gene and lipid and insulin levels. The study population consisted of 102 Hispanic men and 97 Hispanic women. The subjects were genotyped for two previously reported RFLPs detected with the restric