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Genetic markers in primary open-angle glaucoma

✍ Scribed by Emilio Abecia; Begoña Martínez-Jarreta; Yolanda Casalod; Blanca Bell; Isabel Pinilla; Francisco M. Honrubia

Publisher
Springer Netherlands
Year
1997
Tongue
English
Weight
297 KB
Volume
20
Category
Article
ISSN
0165-5701

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✦ Synopsis

Purpose:

To investigate possible associations between genetic markers and primary open-angle glaucoma (poag).

Methods:

A number of genetic markers were typed in 84 unrelated patients with poag and compared with a random sample of healthy individuals. the markers were transferrin, group specific component, g1m (1), g1m (2) and g3m (5) allotypes, adenylate kinase, adenosin deaminase, glyoxalase i and acid phosphatase and pcr-based markers hla-dqa1 and d1s80.

Results:

No significant differences were found except the strong association between the group of poag patients and acid phosphatase acp*c allele (chi 2 = 32.86; p < 0.0001).

Conclusions:

Since acid phosphatase gene is localized to chromosome 2p23, this result could be a first comprehensive step in the localization of poag genes.

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