Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33
✍ Scribed by Kyung Sue Hong; L. Alison McInnes; Susan K. Service; Terry Song; Jennifer Lucas; Sandra Silva; Eduardo Fournier; Pedro León; Julio Molina; Victor I. Reus; Lodewijk A. Sandkuijl; Nelson B. Freimer
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 143 KB
- Volume
- 125B
- Category
- Article
- ISSN
- 1552-4841
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✦ Synopsis
Abstract
We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061–1064] of a locus on 5q predisposing to bipolar I disorder (BP‐I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi‐point non‐parametric linkage analysis (SimWalk2). Significant identity‐by‐descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP‐I gene. These results support the suggestion that a locus at 5q31‐33, together with a previously reported locus at 18q22‐23, may provide the major genetic risk for BP‐I in this family. © 2003 Wiley‐Liss, Inc.