Genetic Mapping of X-Linked Ocular Albinism: Linkage Analysis in a Large Newfoundland Kindred
β Scribed by Stephen J. Charles; Jane S. Green; Anthony T. Moore; David E. Barton; John R.W. Yates
- Book ID
- 115611541
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 137 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0888-7543
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An extensive linkage analysis was performed by studying ten Xp22 loci in ten families segregating for X-linked ocular albinism of the Nettleship-Falls type (XOA). Linkage was confirmed between the XOA locus (OA1) and both DXS16 (theta max = 0.10, zeta max = 4.09) and DXS237 (theta max = 0.12, zeta m
We apply a method proposed by Rogatko et al. [1995: Am J Med Genet 59:24-32] to estimate carrier risks using genetic linkage data. The method is illustrated for X-linked ocular albinism. Linkage data from pedigrees were combined with genome mapping data to compute carrier risks for individuals with