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Genetic mapping of a novel hypotrichosis locus to chromosome 7p21.3–p22.3 in a Pakistani family and screening of the candidate genes

✍ Scribed by Sulman Basit; Ghazanfar Ali; Naveed Wasif; Muhammad Ansar; Wasim Ahmad


Publisher
Springer
Year
2010
Tongue
English
Weight
389 KB
Volume
128
Category
Article
ISSN
0340-6717

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## Abstract Germ‐line mutations in the serine‐threonine kinase gene __STK11__ (__LKB1__) cause Peutz–Jeghers syndrome (PJS), a rare autosomal dominantly inherited disease, characterized by hamartomatous polyposis and mucocutaneous pigmentation. __STK11__ mutations only account for about half of PJS