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Genetic mapping of a locus associated with bovine chronic interstitial nephritis to chromosome 1

✍ Scribed by N Kobayashi; T Hirano; S Maruyama; H Matsuno; K Mukoujima; H Morimoto; H Noike; H Tomimatsu; K Hara; T Itoh; K Imakawa; H Nakayama; T Nakamaru; Y Sugimoto

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 295 KB
Volume: 31
Category: Article
ISSN: 0268-9146
DOI: 10.1046/j.1365-2052.2000.00589.x

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✦ Synopsis

Chronic interstitial nephritis with diffuse zonal fibrosis (CINF) occurs in Japanese Black cattle (Wagyu) as an autosomal recessive disorder leading to death prior to puberty, first six months or a year of life. We performed a genome‐wide scan using microsatellite markers in a Wagyu pedigree segregating for CINF and mapped the CINF locus to bovine chromosome 1. CINF was closest to microsatellites BM9019 and INRA49 (Z score = 12 ·0; P < 3 ·4 × 10^−10^).

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