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Genetic mapping and expression analysis of the murine DNA ligase I gene

✍ Scribed by Manuela Gariboldi; Alessandra Montecucco; Amedeo Columbano; Giovanna M. Ledda-Columbano; Elena Savini; Giacomo Manenti; Marco A. Pierotti; Tommaso A. Dragani

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
390 KB
Volume
14
Category
Article
ISSN
0899-1987

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✦ Synopsis

Abstract

We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver‐cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4–bis[2–(3,5—dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation. ©1995 Wiley‐Liss, Inc.

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