Genetic map of seven polymorphic markers comprising a single linkage group on rat Chromosome 5

✍ Scribed by Ellen A. Goldmuntz; Elaine F. Remmers; Hongbin Zha; Peter Mathern; Ying Du; Leslie J. Crofford; Ronald L. Wilder

• Publisher: Springer-Verlag
• Year: 1993
• Tongue: English
• Weight: 609 KB
• Volume: 4
• Category: Article
• ISSN: 0938-8990
• DOI: 10.1007/bf00360905

✦ Synopsis

Seven polymorphic markers comprising a single linkage group were assigned to rat Chromosome (Chr) 5 by linkage analysis of the progeny of an Fz intercross of Fischer (F344/N) and Lewis (LEW/N) inbred rats. Three genes, oL-L-fucosidase 1 (FUCA1), mitochondrial superoxide dismutase (SOD2), and glucose transporter (GLUT1), were mapped by restriction fragment length polymorphism (RFLP) analysis. Two genes, glucose transporter (GTG3) and elastase II (ELAI1), one pseudogene for o~ tubulin (TUBAPS), and one sequence related to the 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase gene (PFKFBPl-related sequence) were mapped by simple sequence repeat (SSR) polymorphism analysis. The loci are in the following order: SOD2, GTG3/GLUT1, FUCA1, ELAII/ PFKFBPl-related sequence, and TUBAPS. This linkage group covered 68.3 cM of rat Chr 5.