Genetic linkage in the mouse of genes involved in down syndrome and Alzheimer's disease in man
β Scribed by Reeves, Roger H.; Robakis, Nikolaos K.; Oster-Granite, Mary Lou; Wisniewski, Henryk M.; Coyle, Joseph T.; Gearhart, John D.
- Book ID
- 123498913
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 688 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0169-328X
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## Abstract Down syndrome (DS) is the most common genetic cause of significant intellectual disability in the human population, occurring in roughly 1 in 700 live births. The ultimate cause of DS is trisomy of all or part of the set of genes located on chromosome 21. How this trisomy leads to the p
Linkage studies in families with presenile onset of Alzheimer's disease (AD) indicated the presence of a predisposing gene on the proximal long arm of chromosome 21. We mapped four new loci in the candidate AD region using somatic cell hybrids. For three of the four loci, several restriction fragmen