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Genetic linkage analyses redefine the roles of PfCRT and PfMDR1 in drug accumulation and susceptibility in Plasmodium falciparum

✍ Scribed by Cecilia P. Sanchez; Sybille Mayer; Astutiati Nurhasanah; Wilfred D. Stein; Michael Lanzer

Book ID
110837041
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
975 KB
Volume
82
Category
Article
ISSN
0950-382X

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✍ Maha E. Osman; Frank P. Mockenhaupt; Ulrich Bienzle; Mustafa I. Elbashir; Hayder πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 349 KB

Mutations in the Plasmodium falciparum pfcrt gene on chromosome 7 and possibly mutations in pfmdr1 on chromosome 5 have a role in conferring resistance against chloroquine (CQ), as do mutations of pfdhfr on chromosome 4 and pfdhps on chromosome 8 in terms of resistance against sulfadoxine/pyrimetham