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Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

โœ Scribed by Morrison, Ciaran; Smith, Graeme C.M.; Stingl, Laura; Jackson, Stephen P.; Wagner, Erwin F.; Wang, Zhao-Qi

Book ID
109918957
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
439 KB
Volume
17
Category
Article
ISSN
1061-4036

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Recent in vitro work on V(D)J recombination has helped to clarify its mechanism. The first stage of the reaction, which can be reproduced with the purified RAG1 and RAG2 proteins, is a site-specific cleavage that generates the same broken DNA species found in vivo. The cleavage reaction is closely r