Genetic interaction between Non-MHC T- and B-cell alloantigens in response to rous sarcomas in chickens
✍ Scribed by Douglas G. Gilmour; Walter M. Collins; Tom L. Fredericksen; Willard E. Urban; Paul F. Ward; Nancy L. DiFronzo
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 620 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
Chickens of Regional Poultry Research Laboratory (RPRL) inbred line 63 regress sarcomas induced by Bryan high-titer Rous sarcoma virus to a greater extent than chickens of line RPRL 100, although these lines are identical for the major histocompatibility B complex. They differ, however, at three independent autosomal loci: Ly-4 and Th-I determine the surface alloantigens of partly overlapping subsets of T lymphocytes, and Bu-I determines a surface alloantigen of B lymphocytes. The association of genotypes at these loci with quantitative variation in their ability to regress Rous sarcomas was tested in segregating F 4 generation progeny derived from crosses of lines 100 and 63 . The Ly-4 and Bu-i genotypes showed association with Rous sarcoma regression, but the Th-I genotype did not. Chickens of the L y-4a/L y-4 ", Bu-I b/Bu-1 b and L y-4b/L y -4 b, Bu-la/Bu-1" genotypes had a significantly higher regressor ability than the other two double homozygous genotypes. These results indicate that higher regression is associated with (1) interaction between the Ly-4 and Bu-I loci, and (2) complementation between either the line 6 Ly-4 a allele and the line 100 Bu-I b allele, or the line 100 Ly-4 b allele and the line 6 Bu-U allele.