𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Genetic instability in fibroblasts of patients with thyroid cancers (TC)

✍ Scribed by D. B. Krizman; S. Pathak; N. A. Samaan; R. C. Hickey

Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
289 KB
Volume
39
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

In cultured fibroblasts initiated from fresh tumor biopsies of 11 patients with thyroid tumors, 5 medullary carcinoma of the thyroid (MCT) and 6 papillary follicular, the chromosomes are relatively unstable when compared with those from control fibroblast cultures. Tumor-derived fibroblast samples showed a mean number of cells in metaphase with chromosome abnormalities at a frequency of 9.1% and a range of 6-13%, whereas 5 controls exhibited a mean frequency of 4% and a range of 3-5%. Our results indicate that genetic instability in thyroid cancer patients is present not only in peripheral blood cultures, as reported earlier, but in their fibroblast cultures as well.

πŸ“œ SIMILAR VOLUMES

Microsatellite instability in colorectal
Microsatellite instability in colorectal-cancer patients with suspected genetic predisposition
✍ D. Calistri; S. Presciuttini; G. Buonsanti; P. Radice; I. Gazzoli; V. Pensotti; πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 French βš– 67 KB πŸ‘ 2 views

Hereditary non-polyposis colorectal cancer (HNPCC) is a dominantly inherited syndrome linked to DNA-mismatch-repair (MMR) gene defects, which also account for microsatellite instability (MSI) in tumour tissues. Diagnosis is based mainly on family history, according to widely accepted criteria (Amste

Elevated risk of papillary thyroid cance
Elevated risk of papillary thyroid cancer in Korean patients with Hashimoto's thyroiditis
✍ Kyung Won Kim; Young Joo Park; Eun Hye Kim; So Yeon Park; Do Joong Park; Soon-Hy πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 90 KB πŸ‘ 1 views

## Abstract ## Background. Hashimoto's thyroiditis (HT) and higher levels of thyroid‐stimulating hormone (TSH) have been proposed as risk factors for papillary thyroid cancer (PTC), but this issue is still being debated. The purpose of this study was whether HT was related to the risk of PTC over