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Genetic instability in cancer cells by impaired cell cycle checkpoints

✍ Scribed by Makoto Nakanishi; Midori Shimada; Hiroyuki Niida


Book ID
108583726
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
234 KB
Volume
97
Category
Article
ISSN
1347-9032

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Genetic alterations, such as p53 mutations, may affect a tumour's response to chemotherapy. We have treated two human breast cancer cell lines that differ in p53 status with epirubicin in order to study if there are differences in cell cycle kinetic response. MCF-7 cells express wild-type p53, while