Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol and triglyceride levels: Longitudinal apolipoprotein E genotype effects
✍ Scribed by Gail Pairitz Jarvik; Melissa A. Austin; Richard R. Fabsitz; Johan Auwerx; Terry Reed; Joe C. Christian; Samir Deeb
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 613 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
This study addressed the possible influence of apolipoprotein E (apo E) genotype on age-related changes in total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), and triglyceride (TG) levels in older males. Apo E is a component of LDL, is a ligand for the LDL receptor, and apo E genotype has been consistently associated with variation in mean levels of TC and LDL-C, and also appears to influence TG levels. Using male twins followed longitudinally between mean ages of 48 and 63 years, the change in TC, LDL-C, and TG over time for individuals with the € 3 ~3 and the € 3 ~4 genotypes was contrasted. At exam 1 mean TC and LDL-C levels were lower in the € 3 ~3 group than in the € 3 ~4 group, but at exam 3 mean TC and LDL-C levels were significantly higher in the € 3 ~3 group than in the €364 group. The rate of change in TC and LDL-C with age differed significantly between € 3 ~3 and € 3 ~4 groups. Results for TG were not statistically significantly. These findings suggest that the apo E genotype effects on risk of coronary artery disease may be age-dependent. This study demonstrates the value of longitudinal studies in refining models for genetic risk factors for disease. o 1994 Wiley-Liss, Inc.