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Genetic homogeneity between acute and chronic forms of spinal muscular atrophy

✍ Scribed by Gilliam, T. C.; Brzustowicz, L. M.; Castilla, L. H.; Lehner, T.; Penchaszadeh, G. K.; Daniels, R. J.; Byth, B. C.; Knowles, J.; Hislop, J. E.; Shapira, Y.


Book ID
109764042
Publisher
Nature Publishing Group
Year
1990
Tongue
English
Weight
339 KB
Volume
345
Category
Article
ISSN
0028-0836

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A material of 247 cases selected from 260 cases of spinal muscular atrophy in the Warsaw Department of Neurology in 1960-1974 was analyzed. The size of sibships was established and calculations were made of the mean distribution of the age at onset, also according to sex, for the different clinical

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This study provides epidemiological data on acute infantile (ASMA) and chronic childhood spinal (CSMA) muscular atrophy in Warsaw for the period 1976-1985. All calculations are based on the assumption that ASMA and CSMA result from mutations at two different gene loci. The incidence of ASMA and CSMA