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Genetic evidence for the existence of interleukin-23 and for variation in the interleukin-12 and interleukin-12 receptor genes in the horse

✍ Scribed by Petr Kralik; Jan Matiasovic; Petr Horin


Book ID
116344507
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
154 KB
Volume
1
Category
Article
ISSN
1744-117X

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THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPT
✍ Gately, Maurice K.; Renzetti, Louis M.; Magram, Jeanne; Stern, Alvin S.; Adorini πŸ“‚ Article πŸ“… 1998 πŸ› Annual Reviews 🌐 English βš– 258 KB

β–ͺ Abstract  Interleukin-12 (IL-12) is a heterodimeric cytokine that plays a central role in promoting type 1 T helper cell (Th1) responses and, hence, cell-mediated immunity. Its activities are mediated through a high-affinity receptor composed of two subunits, designated Ξ²1 and Ξ²2. Of these two sub