✦ LIBER ✦

Genetic evaluation with data presenting evidence of mixed major gene and polygenic inheritance

✍ Scribed by I. Hoeschele

Publisher: Springer
Year: 1988
Tongue: English
Weight: 934 KB
Volume: 76
Category: Article
ISSN: 0040-5752
DOI: 10.1007/bf00288836

No coin nor oath required. For personal study only.

✦ Synopsis

A procedure for genetic evaluation with field data is proposed for situations in which there is mixed major gene and polygenic inheritance and the major genotype membership of some or of all individuals is unknown. Location parameters (fixed environmental, major genotype and polygenic effects), major genotype frequencies and variance components are estimated by the modal values of joint and marginal posterior distributions. The method is described for continuous and discontinuous data as well as for univariate and multivariate evaluations. Results from a simulation study are presented.

📜 SIMILAR VOLUMES

The mode of inheritance of psoriasis: Ev

The mode of inheritance of psoriasis: Evidence for a major gene as well as a multifactorial component and its implication for genetic counselling

✍ Lennart Iselius; Wick R. Williams 📂 Article 📅 1984 🏛 Springer 🌐 English ⚖ 366 KB

A maternally inherited chromosome 18q22.

A maternally inherited chromosome 18q22.1 deletion in a male with late-presenting diaphragmatic hernia and microphthalmia–evaluation of DSEL as a candidate gene for the diaphragmatic defect

✍ Hatem Zayed; Ryan Chao; Ali Moshrefi; Nelson LopezJimenez; Allen Delaney; Justin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 190 KB 👁 2 views

## Abstract Using an Affymetrix GeneChip® Human Mapping 100K Set to study a patient with a late‐presenting, right‐sided diaphragmatic hernia and microphthalmia, we found a maternally inherited deletion that was 2.7 Mb in size at chromosome 18q22.1. Mapping of this deletion using fluorescence in sit