Genetic epidemiology of persistent islet cell antibodies among IDDM patients

✍ Scribed by Beth Newman; Joseph Selby; Ming Lee; Dr. Mary-Claire King

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 249 KB
• Volume: 6
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370060123

✦ Synopsis

The persistence of cytoplasmic islet cell antibodies (ICA) more than a year after diagnosis of insulin-dependent diabetes mellitus (IDDM) was investigated in 43 families with at least two children with IDDM. The prevalence of persistent ICA among IDDM patients was 16%. Persistence of ICA appeared to be familial in that siblings with IDDM were significantly more concordant for the presence or for the absence of ICA than expected by chance (P=O.O4). Patients with persistent ICA were older on average at onset of IDDM than patients without persistent ICA after adjusting for duration of disease (P=O.o04). Persistence of ICA was not significantly associated with HLA DR type, immunoglobulin genotype, insulin allele class, sex, history of viral diseases, or prior vaccinations.