Genetic epidemiology of differences in low-density lipoprotein (LDL) cholesterol concentration: Possible involvement of variation at the apolipoprotein B gene locus in LDL kinetics
✍ Scribed by R. S. Houlston; P. R. Turner; B. Lewis; S. E. Humphries; D. C. Rao
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 704 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
Abstract
Circulating levels of low‐density lipoprotein (LDL) vary considerably within and between populations, paralleled by differing coronary heart disease (CHD) mortality rates. We have previously shown that variation in the apolipoprotein (apo) B gene as associated with certain restriction fragment length polymorphisms (RFLPs) influences the metabolism of LDL in the U.K. population. To investigate a possible genetic contribution to variation in LDL levels in differing populations we have extended this original study. RFLPs of the apo B gene were determined in samples of individuals from the United Kingdom, Finland, Italy, Spain, and Africa. Significant associations of LDL fractional catabolic rate with the apo B EcoRI and XbaI RFLP genotypes were detected only in the two North European populations. In the African population sample, the XbaI RFLP displayed a significant association with LDL apo B synthesis. The data suggest that variation in the apo B gene influences the metabolism of LDL and that it is different in individuals of different ethnic background.