We are studying the genetic etiology of schizophrenia in the Republic of Palau, a remote island nation in Micronesia that has been geographically and ethnically isolated for approximately 2,000 years. The first epidemiological phase sought to estimate the lifetime prevalence of schizophrenia and eva
Genetic epidemiological study of schizophrenia: Two modes of sampling
โ Scribed by Michail S. Ritsner; Sergei I. Karas; Evgenii I. Drigalenko; Irving I. Gottesman; G. P. Vogler
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 400 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
โฆ Synopsis
The ascertainment of probands according to place of residence in hospitals or in the community has enabled our sampling to be representative of whole subpopulations of patients. Probands from psychiatric hospitals are characterized by biased clinical parameters. Our sampling procedure provides important preliminary results which appear to be contradictory to those produced by conventional sampling methods.
๐ SIMILAR VOLUMES
## Abstract Our genetic epidemiological studies of schizophrenia and other psychotic disorders (SCZ) in the isolated population of Palau have been ongoing for 20 years. Results from the first decade showed that Palau has an elevated prevalence of SCZ and that cases cluster in extended multigenerati
We analyzed two quantitative traits (QI and Q2) provided in the 'Common Disease' data set with the aim of detecting both genetic and environmental determinants. We used linear regression for screening measured variables, maximum likelihood segregation and linkage analyses for detecting and localizin
This paper discusses the need t o account for the sampling scheme in an analysis of epidemiological population data which were collected by a two-stage cluster sample. An example is presented where for validity reasons one should generally account for the sampling scheme, though a rule-of-thumb is g
Previous genetic studies of idiopathic talipes equinovarus (ITEV) suggest an environmental and genetic component to the etiology of ITEV. The present study was undertaken to assess the role of causal factors in the development of ITEV. A total of 285 propositi were ascertained, with detailed family